Therapeutic implications". Molecular Pharmacology. Namespaces Article Talk. Therapeutic Drug Monitoring. In other projects Wikimedia Commons.

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Phenobarbital , also known as phenobarbitone or phenobarb , is a medication recommended by the World Health Organization for the treatment of certain types of epilepsy in developing countries. Side effects include a decreased level of consciousness along with a decreased effort to breathe. Phenobarbital was discovered in and is the oldest still commonly used anti-seizure medication. Phenobarbital is used in the treatment of all types of seizures except absence seizures. Carbamazepine may provide a clinical advantage over phenobarbital for generalized onset tonic-clonic seizures. The first-line drugs for treatment of status epilepticus are benzodiazepines, such as lorazepam or diazepam. If these fail, then phenytoin may be used, with phenobarbital being an alternative in the US, but used only third-line in the UK. Phenobarbital is the first-line choice for the treatment of neonatal seizures. No reliable evidence, though, supports this approach.

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