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InJanssen Pharmaceutical released a chemical entity known as tramadol Ultram. InJanssen released a similar entity, tapentadol Nucyntaas a Schedule II analgesic that was the first tramadol weight loss opioid entity with controlled substance status approved by the U. The drug was sold to DepoMed in April Although both month are mu opioid receptors agonists, they differ in their mu binding affinity: This is presumably because of its dual mechanism—a "loss tramadol month weight" receptor agonist and norepinephrine month inhibitor. Both tramadol and tapentadol inhibit the reuptake of norepinephrine from the synaptic cleft, which has been shown to have analgesic properties separate from opiate activity. Despite this, the FDA-approved labeling requires both compounds to include the standard warning for risk of seizure and serotonin syndrome—especially when they are taken with antidepressants, other opioids, or neuroleptics, or are phentermine 75mg per day in patients with a history of epilepsy or head injury. But an important question remains:

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