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Clonazepam , sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures , panic disorder , and for the movement disorder known as akathisia. Common side effects include sleepiness, poor coordination, and agitation. Clonazepam was initially patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short term management of epilepsy and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam.

Pregabalin , marketed under the brand name Lyrica among others, is a medication used to treat epilepsy , neuropathic pain , fibromyalgia , restless leg syndrome , and generalized anxiety disorder. Common side effects include sleepiness , confusion, trouble with memory, poor coordination , dry mouth, problem with vision, and weight gain. Pregabalin was approved for medical use in the United States in Pregabalin is useful when added to other treatments, when those other treatments are not controlling partial epilepsy. The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy , post-herpetic neuralgia , and central neuropathic pain. Pregabalin is not recommended for certain other types of neuropathic pain such as trigeminal neuralgia [28] and its use in cancer-associated neuropathic pain is controversial. Pregabalin is generally not regarded as efficacious in the treatment of acute pain. The World Federation of Biological Psychiatry recommends pregabalin as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such as SSRIs as first line treatment for obsessive—compulsive disorder and post-traumatic stress disorder. The effects of pregabalin appear after 1 week of use and is similar in effectiveness to lorazepam , alprazolam , and venlafaxine , but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms.

Performance-enhancing substances , also known as performance-enhancing drugs PED , [1] are substances that are used to improve any form of activity performance in humans. A well-known example involves doping in sport , where banned physical performance—enhancing drugs are used by athletes and bodybuilders.

Fluvoxamine , sold under the brand name Luvox among others, is a medication which is used primarily for the treatment of obsessive—compulsive disorder OCD , [4] and is also used to treat major depressive disorder and anxiety disorders such as panic disorder and post-traumatic stress disorder. The FDA has added a black box warning for this drug in reference to increased risks of suicidal thoughts and behavior in young adults and children. Australia , [9] [10] the UK , [11] and Russia [12] it also has indications for major depressive disorder. Some evidence shows fluvoxamine may be a helpful adjunct in the treatment of schizophrenia , improving the depressive, negative, and cognitive symptoms of the disorder. Gastrointestinal side effects are more common in those receiving fluvoxamine than with other SSRIs. Fluvoxamine inhibits the following cytochrome P enzymes:

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