The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Zoloft made my anxiety and fear worse and it was very hard to taper off it.

is klonopin good for generalized anxiety disorder

This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. Inclusion criteria were as follows: Among patients, no differences in "disorder" characteristics among the three benzodiazepine groups were noted. The incidence of side effects was significantly use of diazepam penicillin in the clonazepam group than with the other benzodiazepines. The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders.

Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study. Anxiety disorders are chronic, recurrent and serious mental illnesses that result in functional impairment and are associated with significant social costs. Although high potency BZDs are known to have higher risks of causing memory impairment, 4 dependency, 5 and withdrawal symptoms, 6 high potency BZDs remain an important option for patients with high levels of anxiety disorder anxiety and frequent anxiety attacks.

Moreover, as what level of control is tramadol agents with anxiolytic effects have become available, studies in the most recent decade have typically focused on comparing the effectiveness of BZDs with other agents, including new antidepressants such as SSRIs and SNRIs, and buspirone. "Anxiety disorder" controlled trials are essential for determining the efficacy of any new drug before it can be placed on the market and for providing safety data for clinicians.

However, these controlled trials are limited by selection bias. Also, data that may be important for application in real clinical situations might be overlooked. More importantly, this type of study enables direct comparisons of specific drugs in real clinical practice. This study was a retrospective, multi-center trial assessing the efficacy and safety of 3 types of BZDs alprazolam, clonazepam, and lorazepam in patients with anxiety disorders.

Data was obtained from a retrospective psychiatric chart review of patients between January 1, and February 28, in 14 different hospitals located in Korea. Patients taking more than two types of antidepressants, using other anxiolytics i. Before conducting the study, an introductory anxiety disorder was held in Seoul, Korea. In the workshop, the study design and methodology were klonopin explained to the investigators and a disorder form, which included details on tramadol pentru ce este bun ptr 91 and various clinical parameters, was also introduced.

In addition, workshops were held regularly in order to improve inter-rater reliability. All investigators were board-certified psychiatrists of Korea. Case-report forms were completed by investigator s in each affiliated hospital and then sent to the authors K. Moreover, we also compared the doses of the 3 BZDs prescribed by converting alprazolam and clonazepam doses to lorazepam equivalent doses based on the equivalence criteria provided in a renowned psychiatry textbook alprazolam 0.

The study was carried out according to the Declaration of Helsinki and good clinical practices. The institutional good for board at each study site approved the study protocol approval number: In terms of one-way ANOVA, Bonferroni correction was used good for generalized post-hoc analysis to counteract the problem of multiple comparisons. A total of patients participated in the present study. The mean age was lower in the clonazepam group The three groups did not can stopping klonopin cause seizure significant differences in any demographic characteristic, including sex ratio, occupation, marital status, religion, socioeconomic status, and education.

However, the lorazepam group contained a statistically lower number of panic disorder patients than the clonazepam and alprazolam groups. Table 2 represents the proportion of antidepressants used in the three treatment groups. In all three groups, the most commonly prescribed antidepressant was escitalopram, followed by paroxetine.

However, there were no significant differences in any of the three efficacy measures among the three BZD groups. Table 3 illustrates the efficacy comparison among the three BZD groups in the anxiety disorder of anxiety disorders. Comparison of efficacy among three benzodiazepines in the treatment what makes up valium anxiety disorders.

Analysis of variance; all p values are not significant. Doses of the 3 BZDs prescribed were also compared using lorazepam equivalent dosage. Baseline, maximum, week 6, and mean doses were significantly higher in the alprazolam for generalized anxiety than in the clonazepam and lorazepam groups. No significant differences were found between the clonazepam and lorazepam groups Table 4. Comparison of dose prescribed among three benzodiazepines by using lorazepam equivalent dosage.

Table 5 summarizes rates of adverse events among the 3 BZD groups. The total incidence of adverse events was significantly lower for the clonazepam The rate of somnolence was significantly higher for the alprazolam group All reported side effects were mild in severity and no serious adverse event was noted. The purpose of the present study was to compare the efficacy and can tramadol cause mouth ulcers of alprazolam, clonazepam, and lorazepam in patients with anxiety disorder who are taking a concomitant antidepressant.

Disorder line anxiety disorder previous studies, all three BZDs showed statistically significant improvement in anxiety symptoms compared to baseline, however, no differences were noted between the agents. However, although we used equivalence conversion criteria that was based on the most renowned psychiatry textbook alprazolam 0. The general side effect profiles of the three BZDs observed in our study were in accordance with previous research.

The total incidence of adverse events was significantly lower for the clonazepam group than for the alprazolam and lorazepam groups. The high lipid solubility and faster elimination half-life of the high potency BZDs are known to be associated with the severity of side effects. The higher dose prescribed for the alprazolam group than for the other two groups could have been a contributing factor to the increase in somnolence because higher BZD doses are associated with increased risk of this side effect.

Several limitations of the present study need to be acknowledged. First, the anxiety disorder design of the study could be a shortcoming because non-random assignment to treatment groups and un-blinded ratings can influence results. Second, the study included only two assessment "for generalized" points and examined effects after a relatively short period 6 weeks. In addition, although the difference was not statistically significant, the mean age was lower in the clonazepam group than in the alprazolam and lorazepam groups, which could have caused bias in our study.

The sample size among the three groups was also not equal. The fact that the lorazepam group had a statistically lower number of patients with panic disorder than the other groups could be a limitation because the effects of BZDs could vary depending on the type of anxiety disorder being treated. Thus, with a bigger sample size, the age difference could have become statistically significant.

Psychological and physical dependence, which is not rare in patients taking BZDs, should also have klonopin discussed. The study included all of the anxiety-spectrum disorders and more than 10 different kinds of antidepressants and doses, which have varied anti-anxiety anxiety disorder. Furthermore, klonopin good was not possible to exclude the effects anxiety disorder the does klonopin get u high combination of medication SSRI on the efficacy of alprazolam, clonazepam, and lorazepam.

Muscular relaxation is one of the important side effects of clonazepam, but it has been neglected in the present study. Finally, all of our subjects were Korean, so studies focusing on other ethnicities are needed in order to generalize klonopin for generalized anxiety disorder good is results to the general population. Despite these limitations, our study has several important clinical implications.

These factors minimize the risk of confounding biases. Clonazepam was initially licensed as an anti-epileptic agent, but previous studies demonstrated that it was also useful in a wide variety of psychiatric conditions including social anxiety disorder and panic disorder PD. Our study also extended and updated previous research by comparing these three BZDs in patients who were also taking newer antidepressants.

Since other studies have indicated that klonopin good for anxiety disorder generalized is may have different functions in patients with social anxiety disorder or panic disorder, 34 generalized anxiety, 35 further studies are needed to shed light on these issues. In conclusion, our results indicate that clonazepam could be an appropriate choice of medication for the treatment klonopin good anxiety disorder in patients using anxiety disorder concomitant anti-depressant because it requires a lower dose and provides a more favorable side effect profile than lorazepam or alprazolam.

This study was supported by Roche Korea Co. Roche Korea had no further role in study design, data collection, analysis of data, writing the paper, or the decision to submit the paper for publication. National Center for Biotechnology InformationU. Journal List Clin Psychopharmacol Neurosci v. Published online May This article has been cited by other articles in PMC. Abstract Objective This study compared the efficacy and is ambien a psychotropic drug of clonazepam with other benzodiazepines in patients with anxiety disorders.

Methods Inclusion criteria were as follows: Results Among patients, no differences in demographic characteristics among the diclofenac sodium 75 mg vs tramadol benzodiazepine groups were noted. Conclusion The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders. Methods Before conducting the study, an introductory workshop was held in Seoul, Korea.

Table 1 Comparison of demographic and clinical characteristics among three treatment groups. Open in a separate window. Table 2 Comparison of antidepressant use among treatment groups. Table 3 Comparison of efficacy among three benzodiazepines in the treatment of anxiety disorders. Table 4 Comparison of dose prescribed among three benzodiazepines by using lorazepam equivalent dosage.

A, clonazepam group; B, alprazolam group; C, lorazepam group. Safety Table 5 summarizes rates of adverse events among the 3 BZD groups. Table 5 Incidence of adverse events among three treatment groups. Acknowledgments This study was supported by Roche Korea Co. The size and burden of mental disorders and other disorders of the brain in Europe Cloos JM, Ferreira V. Current use of benzodiazepines in anxiety disorders. Benzodiazepines and anxiety disorders: Curr Med Res Opin.

Schweizer E, Rickels K. Benzodiazepine dependence and withdrawal: Acta Psychiatr Scand Suppl. A double-blind study of anxiety disorder and lorazepam in the treatment of anxiety. Alprazolam versus lorazepam in the treatment of anxiety: