Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for patients with inadequate treatment options.

classification alprazolam therapeutic of

Available forms Available by prescription only Oral solution: Usual starting dose is 0. Maximum total daily dose is 4 mg in divided doses. For geriatric or debilitated patients or those with hepatic impairment, initial dose is 0. Increase as needed and tolerated at intervals of 3 to 4 days in increments of 1 mg daily. Most patients require more than 4 mg daily; however, doses from 1 to 10 mg daily have been reported. Alprazolam depresses the CNS at the limbic and subcortical levels of the brain.

It produces an antianxiety effect by enhancing the effect of the neurotransmitter gamma-aminobutyric acid on its receptor in the ascending reticular activating system, which increases inhibition alprazolam blocks both cortical and limbic arousal. Well absorbed after oral administration. Distributed widely throughout the body. Metabolized in the liver equally to alpha-hydroxyalprazolam and inactive metabolites. Half-life of alprazolam is 12 to 15 hours. Contraindications and precautions Contraindicated in patients hypersensitive to drug or other benzodiazepines and in patients with acute angle-closure glaucoma.

Use cautiously in patients with hepatic, renal, or pulmonary disease, and in is it safe to order ambien online with a history of drug abuse. Antidepressants, therapeutic classification, barbiturates, general anesthetics, MAO inhibitors, alprazolam, phenothiazines: Potentiates CNS depressant alprazolam of these drugs. Diminishes hepatic metabolism of alprazolam, increasing its plasma level. May increase plasma digoxin level.

Monitor serum digoxin level. Benzodiazepines may decrease serum haloperidol level. Monitor patient for effect. May decrease effects of alprazolam. May increase sedative effects of alprazolam. May induce lethargy, increased CNS effects, or coma. Potentiates CNS depressant effects of alcohol. Accelerates alprazolam metabolism, thus lowering clinical alprazolam. Overdose and treatment Signs and symptoms of overdose include somnolence, confusion, coma, hypoactive reflexes, dyspnea, labored breathing, hypotension, bradycardia, slurred classification therapeutic, unsteady gait, and impaired coordination.

Support blood pressure and respiration until drug effects subside; monitor vital signs. Flumazenil, a alprazolam benzodiazepine antagonist, may be useful. Mechanical ventilatory assistance via endotracheal tube may be required to maintain a patent airway and support adequate oxygenation. As needed, use I. If the patient is conscious, induce emesis. Use gastric lavage if ingestion was recent but therapeutic classification if an endotracheal tube is in place to prevent aspiration.

After emesis or lavage, administer activated charcoal with a cathartic as a single dose. Dialysis is of limited value. A 2- to 3-month withdrawal may be necessary, decreasing at no more than 0. Avoid use in breast-feeding women. Use of alprazolam during labor may cause neonatal flaccidity. During start of therapy or after tramadol indications in urine drug screen increase in dose, alprazolam patients who receive drug may need assistance with walking alprazolam activities of daily living.

Advise him to dangle legs for a few minutes before getting out of bed to prevent falls and injury.