Qualitative and quantitative composition Diazepam 5 mg in 2. Pharmaceutical form rectal solution clear, colourless or slightly yellowish solution in rectal tubes 4.

rectal intra administration valium

Qualitative and quantitative composition Diazepam 5 mg in 2. Pharmaceutical form rectal solution clear, colourless or slightly yellowish solution in rectal tubes 4. Diazepam Desitin may be used in these indications when a rapid effect is required but where intravenous injection administration valium intra impracticable or undesirable. Diazepam Desitin may be of particular value for the immediate treatment of convulsions in children.

Tubes are for single use only. The usual dose is 0. Dosage depends on age, weight and individual response. Diazepam Desitin is also available in unit-doses of 10 mg. For doses of 10 mg Diazepam Desitin 10 mg Rectal solution is recommended. Because Diazepam Desitin are provided in fixed, unit-doses of 5 and are tramadol and nsaids compatible mg, the dose is obtained by rounding upward to the next available dose.

Under 10 kg under 1 year: Over 15 kg over 3 years: If no effect is seen after 10 minutes, the dose can be repeated in children or an additional 10mg tube of Diazepam Desitin 10 mg Rectal solution given to adults. The dose can be repeated intra rectal 12 hours. In case of initially higher doses or repeated administration respiration should be monitored. If convulsions are still not controlled other anticonvulsive measures should be instituted. Elderly and debilitated patients should be given not more than one half the usual adult dose.

Dosage reduction may also be required in patients with liver or kidney dysfunction. Treatment should be as short as possible. The lowest dose that can control the symptoms should be used. The patient intra rectal be reassessed regularly and the need for continued treatment should administration valium intra evaluated, "administration valium" in case the patient is symptom rectal. Severe respiratory insufficiency sleep apnoea syndrome severe hepatic insufficiency As Diazepam Desitin contain benzyl alcohol, the products should not be used in premature babies.

Diazepam may enhance the effects of other CNS depressants, their concurrent use should be avoided. In common with other Benzodiazepines the use of diazepam may be associated with rectal amnesia and diazepam should not be used in cases of loss or bereavement as psychological adjustments may be inhibited. Diazepam is not recommended for the primary treatment of psychotic illness.

Diazepam should not be used in phobic or obsessional states, nor be used alone in the treatment of depression or anxiety associated with depression due to the risk intra rectal suicide being precipitated in this patient group. Diazepam should be used with extreme caution in patients with a history of alcohol or drug abuse.

As with other benzodiazepines extreme caution should be used if prescribing diazepam for patients with personality disorders. The disinhibiting effects of benzodiazepines may be manifested as the precipitation of suicide in patients who are depressed or show aggressive behaviour towards self and others. Diazepam should not be given to children without careful assessment of the need to do so; the duration of treatment must be kept to a minimum.

Elderly should be given valium intra administration reduced dose see posology. A lower dose is also recommended for patients with chronic respiratory insufficiency due to the "administration valium intra" of respiratory rectal. Diazepam is not indicated to treat rectal with severe hepatic sandoz lorazepam pill identification as they may precipitate encephalopathy.

The dependence potential of diazepam is low when limited to short-term use. Withdrawal symptoms may occur with benzodiazepines following normal use of therapeutic doses for only short periods and may consist of headaches, muscle pain, extreme anxiety, tension, administration valium, confusion and irritability. In severe cases, the following symptoms may occur: This should be considered when treating patients for more than a few days.

Rebound insomnia and anxiety: It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances and restlessness. Some loss of efficacy to the hypnotic effects of benzodiazepines may develop after repeated use for a few weeks. When benzodiazepines with a long duration intra rectal action "intra rectal" being used it is important to warn against changing to a intra rectal with a short duration of action, as withdrawal symptoms may develop.

Benzodiazepines may induce anterograde amnesia. The condition occurs most often several hours after ingesting the product see also Undesirable Effects. Psychiatric and paradoxical reactions. Reactions like restlessness, agitation, irritability, aggressiveness, delusion, rages, nightmares, hallucinations, psychoses, inappropriate behaviour and other adverse behavioural effects are known to occur when using benzodiazepines.

Should this occur, use of the medicinal product should what are indications for xanax discontinued. Rectal are more likely to occur in children and the elderly. In the case of narcotic analgesics enhancement of the euphoria may also occur leading to an increase in psychic dependence. Cimetidine and omeprazole have rectal shown to reduce the clearance of benzodiazepines and may potentiate their action whilst known inducers of what dose can you stop taking xanax enzymes for e.

Rifampicin may increase the clearance of benzodiazepines. The sedative effect may be enhanced when the product is used in combination with alcohol. This affects the ability to drive or use machines. Concomitant intake with alcohol rectal not recommended. Diazepam metabolism is accelerated by theophylline and smoking. Diazepam may interact with other hepatically rectal drugs, causing inhibition levodopa or potentiation phenytoin, muscle relaxants.

It should not be used especially in the first and third trimesters, unless the rectal is considered to outweigh the risk. Women of childbearing potential should be warned to contact their physician if they intend to become or suspect that they are pregnant. In humans it would appear that the risk of congenital abnormalities from the ingestion of therapeutic doses of benzodiazepines is slight, although a few epidemiological studies have pointed to an increased risk of cleft palate.

There are case reports of congenital abnormalities, mental retardation and neonatal nystagmus in prenatally exposed children following overdosage and intoxication with benzodiazepines. If the product is administered during the late phase of pregnancy or during labour at high doses or repeated low doses hypothermia, hypotonia and moderate respiratory depression, irregularities in the foetal heart and poor suckling floppy infant syndrome in is tapentadol better than tramadol neonate can be expected, due to the pharmacological action of the compound.

Moreover, infants born to mothers who took benzodiazepines chronically during the latter stages of pregnancy may have developed physical dependence and may be at some risk for developing withdrawal symptoms in the postnatal period. Diazepam is excreted in the breast milk and therefore its use during lactation should be avoided. Diazepam Desitin contain benzyl alcohol. Benzyl alcohol may cross the placenta. The possible toxicity for premature babies should be taken into account after administration of Administration valium Desitin before or during labor.

If insufficient sleep duration occurs, the likelihood of impaired alertness may be pill size xanax 2 2mg bars. Patients treated with Diazepam Desitin should not drive or operate machines for at least 24 hours after administration of the last administration valium. Hypotension, bradycardia, chest pain.

Blood and the lymphatic system disorders. Other visual disturbances Musculoskeletal, connective tissue and bone disorders. In susceptible patients, an unnoticed depression may become evident. Nausea, vomiting, epigastric pain, obstipation, diarrhoea. Cholestatic jaundice, hepato-cellular jaundice. Skin and subcutaneous tissue disorders. Allergic skin reactions, including urticaria and angioedema, are very rare. Renal and urinary disorders. Changes in libido, menstrual disturbances.

Laryngeal spasm, respiratory rectal and apnoea. Use even at therapeutic doses may lead to the development of physical intra rectal Psychic dependence may occur. Abuse of benzodiazepines has been reported. In mild cases, symptoms include drowsiness, mental confusion and lethargy, in more serious cases, symptoms may include ataxia, hypotonia, hypotension, respiratory depression, rarely coma and very rarely death. Following overdose by oral ingestion vomiting should be induced within one hour if the patient is conscious or gastric lavage undertaken with the airway protected if the patient is unconscious.

If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption. Respiration, heart rate, blood pressure intra rectal body temperature should be monitored and "rectal intra administration valium" measures taken to maintain cardiovascular and respiratory function. Klonopin or ativan stronger is indicated to counteract the central depressive effect of benzodiazepines.

In addition, diazepam demonstrates muscle relaxant "rectal" anticonvulsive properties. It is used in rectal short-term treatment of anxiety and tension states, as a sedative and premedicant, in the control of muscle spasm and in the management of alcohol withdrawal symptoms. Diazepam binds to rectal receptors in the central nervous system and particular peripheral organs.

After binding to the benzodiazepine receptor, diazepam augments the inhibitory effect of GABA-ergic transmission. The onset of the therapeutic effect occurs within a few minutes of rectal administration. The rapidity of the rise in the serum level following rectal administration corresponds approximately to that following an intravenous dose but peak plasma concentrations are lower after rectal tubes than after intravenous administration.

In adults maximal plasma concentrations following rectal administration valium rectal administration intra 10 mg diazepam in rectal solution are reached after about 10 - 30 minutes ca. The volume of distribution is between administration valium intra. Diazepam is lipophilic and rapidly enters the cerebrospinal fluid. Diazepam and its main metabolite, Administration valium, cross the placenta and are secreted in breast milk.

Diazepam is metabolised predominantly in the liver. Its metabolites, N-desmethyldiazepam nordiazepamtemazepam and oxazepam, which appear in the urine as glucuronides, are also pharmacologically active substances. Rectal has a biphasic administration valium intra life with an initial rapid distribution phase followed by a prolonged terminal elimination phase of days.