alprazolam mylan 0 50 mg

Alprazolamavailable under the trade name Xanaxis a potentshort-acting benzodiazepine anxiolytic —a minor tranquilizer. It possesses anxiolyticsedativehypnoticskeletal muscle relaxantanticonvulsantamnesticand antidepressant properties. Greatest alleviation of generalized anxiety disorder GAD may take up to a week. Alprazolam was first released by Upjohn now a part of Pfizer in As ofalprazolam is the mixing ambien and cough syrup prescribed [14] and the most misused benzodiazepine in the US.

Xanax has gained attention by the media as young people have been alprazolam mylan it on the Internet illegally. Most people alprazolam mylan have bought it have been in their 20s or 30s. Alprazolam is mostly used to treat anxiety disorderspanic disordersand nausea due to chemotherapy. Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Alprazolam is no longer recommended in Australia for the treatment of panic disorder due to concerns regarding tolerance, dependence, and abuse.

However, people with panic disorder have been treated on mylan alprazolam open basis for up to 8 months without apparent loss of benefit. In the United States, alprazolam is FDA-approved for the treatment of panic disorder with or without agoraphobia. Anxiety associated with depression is responsive to alprazolam. Clinical studies have shown that the effectiveness is limited to 4 months for anxiety disorders.

In the UK, alprazolam mylan is recommended for the short-term treatment 2—4 weeks of severe acute anxiety. Alprazolam may be used in combination with other medications for chemotherapy-induced nausea and vomiting. Benzodiazepines cross the placentaenter the fetusand are also excreted in breast milk. Chronic administration of diazepamanother benzodiazepine, to nursing mothers has been reported to cause their infants to become lethargic and to lose weight.

The use of alprazolam during pregnancy is associated with congenital abnormalities[1] [26] and use in the last trimester may cause fetal drug dependence and withdrawal symptoms in the post-natal period alprazolam mylan well as neonatal flaccidity and respiratory problems. Spontaneous abortions may also result from abrupt withdrawal of psychotropic medications, including benzodiazepines.

Benzodiazepines require special precaution if used in children and in alcohol- or drug-dependent individuals. Particular care should be taken in pregnant or elderly people, people with substance abuse history particularly alcohol dependenceand people with comorbid psychiatric disorders. Like all central nervous system depressantsmg 50 alprazolam 0 mylan in larger-than-normal doses can cause significant deterioration in alertness and increase drowsiness, especially in those unaccustomed to the drug's effects.

Elderly individuals should be cautious in the use of alprazolam due to the possibility alprazolam mylan increased susceptibility to side-effects, especially loss of coordination and drowsiness. Sedative drugs, including alprazolam, have been associated with an increased risk of death. Possible side alprazolam mylan include:. Although unusual, the following paradoxical reactions have been shown to occur:. Alprazolam is primarily metabolized via CYP3A4.

Alcohol is one of the most common interactions; alcohol and alprazolam taken in combination have a synergistic effect on one another, which can cause severe sedation, behavioral changes, and intoxication. The more alcohol and alprazolam taken, the worse the interaction. John's wort conversely can lower the plasma levels of alprazolam and reduce its therapeutic effect.

Overdoses of alprazolam can be mild to severe depending on the quantity ingested and if other drugs are taken in combination. Alprazolam mylan 0 50 mg alprazolam cause excess central nervous system CNS depression and may include one or more of the following symptoms: Alprazolam, like other benzodiazepines, binds to specific sites on the GABA A gamma-aminobutyric acid receptor.

Long-term use causes adaptive changes in the benzodiazepine receptors, making alprazolam mylan less sensitive to stimulation and thus alprazolam mylan the drugs less potent. Withdrawal and rebound symptoms commonly occur and necessitate a gradual reduction in dosage to minimize withdrawal effects alprazolam mylan discontinuing.

Not all withdrawal effects are evidence of true dependence or withdrawal. Recurrence of symptoms such as anxiety may simply indicate that the drug was having its expected anti-anxiety effect and that, in the absence of the drug, the symptom has returned to pretreatment levels. If the symptoms are more severe or frequent, the person may be experiencing a rebound effect due to the removal of the drug.

Either of these can occur without the person actually being drug-dependent. Alprazolam and other benzodiazepines may also cause the development of physical dependencetoleranceand benzodiazepine withdrawal symptoms during rapid dose reduction or cessation of therapy after long-term treatment. How to spot xanax abuseRomach and colleagues reported that dose escalation is not a characteristic of long-term alprazolam users, and that the majority of long-term alprazolam users change their initial pattern of regular use to one of symptom control only when required.

Some common symptoms of alprazolam discontinuation include malaiseweakness, insomniatachycardia how long does tramadol take to leave your system, lightheadedness, and dizziness. This medication may cause withdrawal symptoms upon abrupt withdrawal or rapid tapering, which in some cases have been known to cause seizures, as well as marked delirium similar to mylan 50 alprazolam mg 0 produced by the anticholinergic tropane alkaloids of Datura scopolamine and atropine.

To some degree, these older benzodiazepines are self-tapering. Factors that determine the risk of psychological dependence or physical dependence and the severity of the benzodiazepine withdrawal symptoms during dose reduction of alprazolam include: Alprazolam may be quantified in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in mylan alprazolam impaired driving arrest, or to assist in a medicolegal death investigation.

Most commercial immunoassays alprazolam mylan the benzodiazepine class of drugs cross-react with alprazolam, but confirmation and quantitation is usually performed using chromatographic techniques. Alprazolam mylan is classed as a high-potency triazolobenzodiazepine: As a benzodiazepine, alprazolam produces a variety of therapeutic and adverse effects by binding to the benzodiazepine receptor site on the GABA A receptor and modulating its function; GABA receptor s are the most prolific inhibitory receptor within the brain.

The GABA chemical and receptor system mediates inhibitory or calming effects of alprazolam on the nervous system. The GABA A receptor is made up of 5 subunits out of a possible 19, and GABA A receptors made up of different combinations of subunits have different properties, different locations within the brain, and, importantly, different activities with regard to benzodiazepines. Alprazolam and other triazolobenzodiazepines such as triazolam that have a triazole ring fused to their diazepine ring appear to have antidepressant properties.

Alprazolam causes a marked suppression of the hypothalamicpituitary-adrenal axis. The therapeutic properties of alprazolam are similar to other benzodiazepines and include anxiolyticanticonvulsantmuscle relaxanthypnotic [78] and amnesic ; however, it is used mainly as an anxiolytic. Administration of alprazolam, as compared to lorazepamhas been demonstrated to elicit a statistically significant increase in extracellular dopamine D1 and D2 concentrations in the striatum.

The concentration of alprazolam peaks after one to two hours. Two major metabolites are produced: Klonopin .25 mg dose metabolites, as well as some unmetabolized alprazolam, are filtered out by the kidneys and are excreted in the urine. Alprazolam regular release and orally disintegrating tablets are available as 0. Alprazolam oral solutions are available as 0.

Inactive ingredients in alprazolam tablets and solutions include microcrystalline cellulose alprazolam mylan, corn starchdocusate sodiumpovidonesodium starch glycollate, lactose monohydrate, magnesium stearatecolloidal silicon dioxideand sodium benzoate. In addition, the 0. Alprazolam is covered under U. Patent 3,which was filed on 29 Octobergranted on 19 Octoberand expired in September There is a risk of misuse and dependence in both patients and non-medical users of alprazolam; alprazolam's high affinity binding, alprazolam mylan potency, and rapid onset increase its abuse potential.

The physical dependence and withdrawal syndrome of alprazolam also add to its addictive nature. In the small subgroup of individuals who escalate their doses there is usually a history of alcohol or other substance use disorders. Alprazolam is one of the most commonly prescribed and misused benzodiazepines in the United States. Men and women are equally likely to use benzodiazepines recreationally. The report found that alprazolam is the most common benzodiazepine for recreational use, followed by clonazepamlorazepamand alprazolam mylan. Alprazolam, along with other benzodiazepines, is often used with other recreational drugs.

These uses include aids to relieve the panic or distress of dysphoric " bad trip " reactions to psychedelic drugssuch as LSDand the drug-induced agitation and insomnia alprazolam mylan the " comedown " stages of stimulant use, such as amphetaminecocaineand MDMA allowing sleep. Alprazolam may also be used with other adderall and xanax speedball drugssuch as ethanolheroinand other opioidsin an attempt to enhance their psychological effects.

Alprazolam may be used in conjunction with cannabiswith users citing a synergistic effect achieved after consuming the combination. The poly-drug use of powerful depressant drugs poses the highest level of alprazolam mylan concerns due to a significant increase in the likelihood of experiencing an overdosewhich may lorazepam side effects in elderly fatal respiratory depression.

A study claimed that diazepam has a higher misuse potential relative to other benzodiazepines, and that some data suggests that alprazolam and lorazepam resemble diazepam in this respect. Anecdotally injection of alprazolam has been reported, causing dangerous damage to boostin bioavailability of klonopin alprazolam mylan, closure of blood vessels embolization and decay of muscle tissue rhabdomyolysis.

Slang terms for alprazolam vary from place to place. Some of the more common terms are modified versions of the trade name "Xanax", such as Xannies or Xanies and the phonetic equivalent of Zannies; [95] [96] references to their drug classes, such as benzos or downers; or remark upon alprazolam mylan shape or color most commonly a straight, perforated tablet or an oval-shaped pill: Alprazolam is available in English-speaking countries under the following brand names: As of Decemberin anticipation of the rescheduling of alprazolam to Schedule 8 in Australia—Pfizer Australia announced they would be discontinuing the Xanax brand in Australia as it is no longer commercially viable.

From Wikipedia, the free encyclopedia. For other uses, alprazolam mylan Xanax disambiguation. D Evidence of risk. Benzodiazepine dependence and Benzodiazepine withdrawal syndrome. Drugs Phentermine taken with tramadol the Spectrum. Retrieved 14 September Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic Demonstrations of the effectiveness of XANAX by systematic clinical study are limited to 4 months duration for anxiety disorder and 4 to 10 weeks duration for panic disorder; however, patients with panic disorder have been treated on an open basis without any apparent loss of benefit.

The physician should periodically reassess the usefulness of the drug for the individual patient. The Most Popular Prescription Drugs". Retrieved 16 June A Review of the Literature". Comprehensive Review of Psychiatry. Principles and Practice of Psychopharmacotherapy 5th ed. Retrieved 22 January The primary care companion for CNS disorders. A Dose of Sanity: