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30/10/2016

Mechanism of action of lorazepam

Lorazepam mechanism of action of

of of mechanism lorazepam action

Lorazepam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. All benzodiazepines cause a dose-related central nervous system depressant activity. Lorazepam is contraindicated in patients with hypersensitivity to benzodiazepines or to any components of the formulation, in acute narrow-angle glaucoma, pre-existing CNS depression, coma, acute pulmonary insufficiency or sleep apnea.

Encephalopathy may be precipitated in patients with severe hepatic insufficiency. The common side effects seen are drowsiness, ataxia, irritability, lightheadedness, dysarthria and disinhibition. Occasionally, confusion, hangover, headache, dizziness, blurred vision, depression and hallucinations have been seen. Withdrawal symptoms on long term usage: CNS depressants- anaesthetics, opioids, antihistamines, baclofen, barbiturates, antipsychotics, anxiolytics, antidepressants: A benzodiazepine used as an anti-anxiety agent with few side effects.

It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. A 12 year old child presented with pain for last year. An infant is vaccinated against bcg at birth but no "mechanism of action of lorazepam" appeared after 12 weeks. Some children often complaint that when they shake their head they feed their brain is moving.

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