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13/11/2016

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A barbiturate [a] is a drug that acts as a central nervous system depressant , and can therefore produce a wide spectrum of effects, from mild sedation to death. Barbiturates are effective as anxiolytics , hypnotics , and anticonvulsants , but have physical and psychological addiction potential. They have largely been replaced by benzodiazepines in routine medical practice, particularly in the treatment of anxiety and insomnia, due to the significantly lower risk of addiction and overdose and the lack of an antidote for barbiturate overdose. Despite this, barbiturates are still in use for various purposes: The name barbiturate originates from the fact that they are all chemical derivatives of barbituric acid. Barbiturates such as phenobarbital were long used as anxiolytics and hypnotics , but today have been largely replaced by benzodiazepines for these purposes because the latter are less toxic in overdose. Barbiturates in high doses are used for physician-assisted suicide , and in combination with a muscle relaxant for euthanasia and for capital punishment by lethal injection.

Buspirone , sold under the brand name Buspar , is an anxiolytic drug that is primarily used to treat generalized anxiety disorder GAD. Buspirone is not considered to be a drug-of-abuse, is safer in overdose than traditional anxiolytics , and is significantly less impairing at therapeutic doses. Buspirone is approved in the United States by the Food and Drug Administration FDA for the short- or long-term treatment of anxiety disorders or can also be used for the short-term relief of the symptoms of anxiety. Buspirone has no immediate anxiolytic effects, and hence has a delayed onset of action ; its full clinical effectiveness may require 2 to 4 weeks to manifest. There is evidence that buspirone may be used to treat cerebellar ataxia. There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder HSDD in women. Several clinical trials , most randomized double-blind trials and in one buspirone was used as an adjunct to atomoxetine and one open-label , have been conducted to evaluate the utility of buspirone in the treatment of attention deficit hyperactivity disorder ADHD , with mostly positive results. Buspirone may be useful in the management of irritability , agitation , and aggression in older patients with dementia and in pediatrics, although further research is necessary to more clearly establish its effectiveness.

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