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Kind code of ref document: Country of ref document: Ref legal event code: Year of fee payment: Prolonged release morphine sulfate I microgranules, comprising neutral carrier particles coated with an active layer and a prolonged release layer, is new. The prolonged release layer tramadol contient il de la morphine a a methacrylic acid-methyl methacrylate copolymer in which the ratio of free carboxy groups to ester groups is 0. Independent claims are included for:

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