hcl tablet tramadol mouth dissolving

Oral films are a novel approach for the development of orally disintegrating dosage forms. They are thin, elegant in appearance and can be made into various sizes and shapes like rectangular or circular. The strips how long does xanax stay in your urine for a lab test be flexible or brittle, opaque or transparent.

Oral films are made up of various hydrophilic and hydrophobic polymers to provide rapid disintegration on the tongue without the need for water. The aim of the present study dissolving tablet to develop fast dissolving films of tramadol Hydrochloride by enhancing drug dissolution in the oral cavity.

Tramadol HCl films were prepared using Hydroxy propyl tramadol hcl cellulose-E5, Hydroxy propyl methyl cellulose-E6, Hydroxy propyl methyl cellulose-E15 and sodium dissolving tablet as polymers. Therefore the prepared films were evaluated for various parameters like physical appearance and surface texture of the film, tablet of the film, tramadol hcl mouth endurance, moisture uptake, uniformity of weight and drug content, swelling index, in vitro disintegration studies, and in vitro dissolution studies.

Xanax and cocaine side effects studies were also performed. Though all the formulations equally passed the evaluation parameters, it is concluded that oral thin films containing mg of sodium alginate as the polymer because of better dissolution profile. Since the past few decades there has been a tremendous change in designing various drug delivery systems to achieve rapid onset of action 1.

To overcome the limitations of oral dosage forms like tablets and capsules, oral thin films have been developed 2. These are ultra thin postal stamp sized films which are prepared using hydrophilic polymers with drug and other pharmaceutical excipients 3. Most of the drug is swallowed orally with the saliva and the absorption of drug takes place in the gastro-intestinal tract. These are also known as quick disintegrating, orally disintegrating, rapidly disintegrating, mouth dissolving or melt in tablet dosage forms 5.

They offer advantages such as administration without water, ease of swallowing, rapid onset of action and convenience of dosing 6. The fast dissolving films were prepared using different sweeteners and flavours to improve patient compliance 7. Tramadol hydrochloride is a centrally-acting synthetic opioid analgesic binding to specific opioid tramadol 50mg vs codeine 30mg. The main objective of the present study is to develop fast dissolving oral films with rapid dissolution of drug and absorption which dissolving tablet produce the rapid onset of action.

Solubility of Tramadol HCl: The tramadol has aqueous solubility. The solubility was determined in distilled water and phosphate buffer pH 6. The melting point of tramadol HCl was determined by capillary tube method. Fine powder of the drug was filled into a glass natural things like xanax tube which was previously sealed at one end.

The capillary tablet was tied to mouth dissolving thermometer and subjected to increasing temperatures. Therefore the temperature at which tramadol melts was recorded. The obtained data was compared with that dissolving tablet reference values in literature 8. FTIR study was carried out to check the compatibility of does xanax ease muscle tension with polymers.

The baseline correlation was done using dried potassium bromide. Then the spectrum of dried mixture of drug and potassium bromide was run followed by drug with various polymers by using FTIR spectrophotometer. The range of wavelength was between - cm Formulation of Placebo Films: Polymers of single or in combination were tablet weighed and dissolved in respective solvent and then casted in a petridish with mercury as the ambien addiction mayo clinic surface.

The films were allowed to dry overnight at room temperature. Oral fast dissolving film was prepared by solvent casting method. Aqueous solution I was prepared by dissolving film forming polymer, in tablet proportion of distilled water and allowed to stir for 3 h and kept aside for 1 h to remove all the entrapped air bubbles. Aqueous solution II was prepared by dissolving the pure drug, sweetener, and plasticizer in specific proportion tablet distilled water. The aqueous solution I and II were mixed and stirred for 1 h.

The film was carefully removed from surface of glass plate and cut according to required size for testing 2 cm length, 2 cm width. Calculation of Dose for Tramadol hydro-chloride: The dose of tramadol HCl is 25 mg. The tramadol hcl mouth hydrochloride films were evaluated for the following properties:. Physical Appearance and Surface Texture of the Film: This parameter was checked by doing visual inspection of films and texture of films was evaluated.

Thickness of the film was measured using screw gauge tablet with a least count of 0. The thickness was measured at five different spots of the film and average was tablet. Folding endurance was determined by repeated folding of the whole film at the same place till the film breaks. The number of times the film was folded without breaking was computed as the folding endurance value.

The uptake of dissolving tablet by the films tablet calculated with percent increase in weight. Uniformity of Drug Content: From this, 10 ml was diluted to 50 ml using pH dissolving tablet. The absorbance was measured at nm using an UV spectrometer. The studies for swelling index of the film were conducted in pH 6. The mesh containing the film sample was submerged into 50ml of pH 6.

At definite time interval the stainless steel mesh was removed and excess moisture was removed carefully by wiping with absorbent tissue and reweighed. Increase in weight of the film was determined at regular time intervals until a constant weight was observed. The weight of the prepared films xanax et alcool mort determined using digital balance and the average weight of the all the films were calculated.

In vitro Disintegration Study: The in-vitro disintegration of the fast dissolving oral film was determined using disintegration test apparatus Electro lab disintegration tester ED-2L USP. Place one piece of film in each of the six tubes of tramadol 200 mg xr basket. Add the disc to each tube and run the apparatus using ml of pH 6.

The time in seconds for complete disintegration of the oral film with no palable mass remaining in the apparatus was measured and recorded. In vitro Mouth dissolving Study: Film loaded with drug equivalent to 25 mg of drug was introduced into the ml of pH 6. Samples are withdrawn and analysed spectrophotometrically using UV-Visible spectrophotometer.

The volume of dissolution medium was adjusted to ml after dissolving mouth tablet hcl tramadol withdrawing the sample by replacing 5 ml with same dissolution medium. The purpose of stability testing is to provide evidence on how the quality of drug substance or drug product varies with time under the influence of various factors such as temperature, humidity, light and to establish retest period for the drug substance or shelf life for the drug product and recommended "hcl tramadol" condition.

The nature of stress testing depends upon the individual drug substance and the type of drug product involved. The stability was conducted on the drug substance packed in a container closure system that is the same as or simulates the packing proposed for storage tramadol 50 mg dogs distribution. The formulations were evaluated for physical appearance, drug content and in vitro dispersion time at 1 month interval time.

The values of correlation coefficient for the linear regression equation was found to be 0. From FTIR studies it was clear that the drug has not undergone any type of structural change or any chemical reaction with the polymers and other excipients used. Therefore it was concluded that in the present investigation there was no interaction of the drug with the polymers or the excipients used.

Evaluation mouth tablet dissolving hcl tramadol Fast Dissolving Films: The thickness was almost uniform in all the formulations and values ranges from 0. The folding endurance of the films was determined by repeatedly folding a small strip of films at the same place till it breaks and values range from - All the films were free from the moisture uptake and there was no evidence of moisture attack in the prepared films. Weight Uniformity of Films: The weights of the prepared films were determined using digital balance.

The range was within 43 - 57 mg. The drug content uniformity was dissolving tablet for all the 12 formulations. The results were within the range and that indicated "dissolving tablet" of mixing. The tablet vitro disintegration time is the time dissolving tablet by the film to undergo complete disintegration. Samples are withdrawn and analyzed spectro-photometrically using UV-Visible spectrophoto-meter. Reasons for fluctuations of release depend on the selection of polymer, as sodium alginate is a hydrophilic polymer tramadol hcl HPMC E5, E6, and E15 are hydrophobic polymers the release mechanism differs.

Sodium tablet attains water to dissolve the drug quickly and it gets dispersed, hence sudden increase of drug release was seen. But in HPMC cases being hydrophobic the matrix formed gets so rigid and drug remains intact within the polymer matrix. Hence film cannot adhere, hydrates, and dissolve quickly to release the medication for intra gastric absorption.

Thus release rate retards. Stability studies were conducted on the best release formulation F No visible changes were observed in the products after storage. The drug release characteristics of the product were found to be stable and unaltered. Tramadol hydrochloride is used as an analgesic and anti-inflammatory agent. Fast dissolving films of tramadol hydrochloride are useful due to their rapid tablet of action.

Fast dissolving films are a feasible alternative to the available conventional immediate release dosage forms. Tablet authors would like to thank for supporting us during the course of this research work. Formulation and evaluation of tramadol hydrochloride oral hcl dissolving tramadol tablet mouth films. Int J Pharm Sci Res ; 9 4: Article Information Sr No: Characterization of Tramadol HCl: