Diazepam for febrile seizure

Major cohort studies document that the long-term prognosis diazepam for most children with febrile convulsions FC is excellent. The 2 main treatment alternatives so far have been long-term prophylaxis with phenobarbital or valproate or no prophylaxis at all. Phenobarbital at times of fever is ineffective and obsolete.

Consensus has emerged that long-term prophylaxis with antiepileptic drugs is rarely justified in FC considering the side effects and the favourable prognosis. No treatment at all does not appear quite satisfactory either, as FC have a seizure recurrence rate, disrupt family life and may have emotional consequences for the family. Moreover, all FC children face a risk, although admittedly low, of subsequent long-lasting potentially central nervous system Drug interactions with xanax and hydrocodone -damaging seizures.

However, 2 further options exist: Several clinical trials have confirmed that intermittent diazepam prophylaxis by way of a few doses seizure the drug per year provides effective seizure control and reduces the recurrence rate by one half or two thirds. The treatment is feasible and cheap, well tolerated by the child tramadol for back pain uk well accepted by the parents. Compliance febrile seizure are common and only partly abatable.

Trivial side effects are frequent. Transient respiratory apnoea does occur, but 15 years' experience substantiates that serious side effects are remarkably rare. Acute anticonvulsant treatment with rectal diazepam in solution given by the parents to stop ongoing seizures and to prevent febrile seizure recurrences is an attractive alternative.

It is feasible, is probably effective and minimizes the use of drugs, but compliance problems are common and protracted seizures are not always controlled. The subsequent management should include a risk profile approach considering a combination of risk factors for new Seizure rather than seizure single factor. By means of a risk index, based on simple clinical data including age febrile diazepam seizure for onset, family seizure history, seizure type and frequency of fever, children may be identified as being at low, intermediate or high risk for further febrile fits.

However, risk factors for new FC and not for subsequent epilepsy "diazepam for febrile" be used. It is concluded that preventing or abbreviating new FC with benzodiazepines appears to be a useful, although not ideal, drug-minimizing approach in managing many children with simple or complex FC. From a health hazard viewpoint, treatment is not for febrile seizure diazepam mandatory, although advisable. A selective strategy seems rational.

Intermittent diazepam prophylaxis may preferably be offered to children at high risk for new FC.